VHL is a genetic systemic condition with the potential for
multi-organ manifestations1

VHL gene mutations predispose patients to the development of cysts and tumors in several systems and organs.1,4

  • Cysts and tumors can grow
    and negatively affect the
    organs and structures
    around them.3
  • Some tumors, such as those
    found in the kidneys and
    pancreas, may become

VHL disease affects 1 in 36,000 live births1

While the average age of VHL onset is 26 years old, manifestations
of the disease can appear in individuals as young as 1 year old.4,6

Review diagnostic criteria >